TWINE renders in 240p, so in this situation each rendered pixel should ideally equal 4x4 on-screen pixels similar to how, with the default windowed size, every rendered pixel equal 2x2 on-screen pixels.
However, I noticed something odd when the window was maximized that wasn't present when the window was, well, windowed - there was a bit of a dithering-like effect going on.
This is easily spotted if you let the title screen gameplay demo run until the game/emulator freezes, at which point look at the middle of the laser sight and/or just above the brightest part of the barrel on the handgun.
Heres a cropped and 200% zoomed-in screenshot showing the dithering-like effect:
- maximized @ 1280x1024.png (10.76 KiB) Viewed 12318 times